Antiepileptic agents--primidone, phenobarbital, phenytoin, and carbamazepine by reversed-phase liquid chromatography.
نویسندگان
چکیده
SubmitBenjamin Gerson, Department of ters: Pathology, New England Deaconess Hospital, and the Harvard Medical School, Boston, MA 02215 Frances Bell, Department of Pathology, New England Deaconess Hospital, Boston, MA 02215 Sum Chan, Poly Drag, Inc., Boston, MA 02215 Evaluators: Larry A. Broussard, Medical Laboratory Associates, Birmingham, AL 35256 Frank M. Stearns and Robert Dairymple, Damon Clinical Laboratories, Trevose, PA 19047 Assigned Christopher S. Frings, Medical Editor: Laboratory Associate8, Birmingham,
منابع مشابه
Simultaneous measurement of ethosuximide, primidone, phenobarbital, phenytoin, carbamazepine, and their bioactive metabolites by liquid chromatography.
A simple, isocratic liquid-chromatographic method was developed for simultaneously measuring ethosuximide, primidone, phenobarbital, phenytoin, carbamazepine, and their bioactive metabolites within 10 min. The chromatographic system involves a Waters' Radial-NOVA PAK C18 reversed-phase column and acetone/methanol/acetonitrile/10 mmol/L phosphate buffer (10/21/8/61 by vol, pH adjusted to 7.95 wi...
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We describe a method for the simultaneous liquid-chromatographic determination of ethosuximide, ethylphenacemide, primidone, phenobarbital, carbamazepine, and phenytoin in serum. The drugs, together with an internal standard, are extracted into ethyl acetate at pH 7.0. The extract is analyzed isocratically at ambient temperature on a reversed-phase column of "SAS Hypersil" with a mobile phase o...
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We describe a sensitive, specific, and very fast liquid-chromatographic assay for simultaneously determining five anticonvulsants (ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine) by using commercially available 5- or 3-microns particle size reversed-phase columns and a microflow-cell-equipped ultraviolet detector. The anticonvulsant drugs are extracted from 200 microL of s...
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متن کاملImproved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum.
We describe an improved "high-pressure" liquid-chromatographic assay for simultaneous determination in serum of the five major antiepileptic drugs (ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine) and N-desmethylmethsuximide (the compound that must be quantitated for therapeutic drug monitoring of the antiepileptic drug methsuximide). Serum protein is precipitated with an a...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 30 1 شماره
صفحات -
تاریخ انتشار 1984